I Am Jazz focuses on the "Jennings" family (the surname "Jennings" is a pseudonym, and any reference to the family's exact location is obscured) and their day-to-day lives. Jazz, who was about to enter high school when the series started in 2015, grapples with the usual teen angst in addition to her own challenges as a transgender girl. Her family, which includes her three siblings, parents and grandparents, also talk about their experiences.